Saturday, October 24, 2009

Allostasis and Addiction

The concept of addiction, in medical jargon, a psychiatric disorder that is manifested by abnormal and obsessive desire enjoyment of certain activities such as drug addiction, alcoholism, gambling, video game, crime, addiction to work is money to eat much, pornographic, or nicotine addiction. In the Indeed, there is no end to the list, but since these substances or activities always brings negative impact on the individual and social life, they are particularlyprovided. Addiction can be described as a compulsive obsession, and create excessive psychological dependence in addicts on individual preferences.

However, the term addiction is often used to mean psychological dependence, and usually connected to drugs or drug abuse problems. But it is also used for problems such as compulsive or excessive eating, although they do not recognize medical community as problems of addiction. There SearchesSubstance, are not related, such as gaming and computer addiction is. In this kind of addiction cases, a recurring compulsion felt by the individual to engage in an activity without regard to its harmful consequences.

Various forms of addiction
In the United States, the term "addiction" is not in the Diagnostic and Statistical Manual Disorders (DSM-IV-TR), instead it uses substance dependence "for the physical addiction,Abuse, or deprived of any substances or drugs. The section states ".... Substance dependence When an individual is the use of alcohol or other drugs despite problems related to substance use, substance dependence is diagnosed. Compulsive and repetitive use may cause tolerance to the effects of the drug and withdrawal symptoms when use is reduced or stopped. This, coupled with drug abuse, substance use disorders are ........" Terminology is dividedbetween psychiatrists and physicians, as a former call this problem or a disease as a psychological dependence or addiction and later as a physical substance or dependency.

Now there is trend to distinguish between physical dependence on withdrawal symptoms and psychological addiction to "compulsive, uncontrolled use of" manifestation "characterized by its own without any harm or suffering. Clinically, it is a "coercive" but not necessarily known as addiction.

There is aless known factor as a pseudo-addiction. This happens when a patient is drug after it with being treated for a long time. This reflects psychological dependence or addiction, but eventually may happen so that the patient could be treated at as well have been his. Such cases are numerous, if patients with opiate drugs, in order to be treated by relieving pain. The treatment of them usually sufficient to remove such dependence. Further studies are necessary for the effectiveness orReplacement of addictive drugs such as opiates.

Allostasis: What is it?
When is a person, drug addiction or inclined, he or she appears, enter a new state as allostatic state deviate from the normal levels of change in an orderly condition. Allostasis is a process of maintaining stability when changing behavioral and physiological functions. Damages the brain of drug addicts and pathological body throughState, discovered damage allostatic load. The result of the allostatic load is a constant state of depression, resulting from allostatic changes. This forces the drug addicts before their brain and body back to looking normal allostatic levels, so that a constant stress. It is observed that the presence of evidence of acute stressors inducing drug seeking tendencies.

Allostasis is a new concept proposed by Sterling and Eyer in 1988. This is aProcess that ensures the stability in an emergency and is endogenously in our physiological system to keep his balance. The word derives allostasis and homeostasis of the original Greek word "homeopathy" means "equal" and stasis means "stable", as homeostasis means "to remain stable from the same". So with the word allostasis, in Greek "allo" means "variable" and statistical means "stable", so allostasis means "to remain stable, by variable". Allostasis is a process to achieveStability through physiological or behavioral changes, and this can be through an amendment be made HPA axis (hypothalamic-pituitary-adrenal axis), hormones, cytokines, autonomic nervous system, or many other systems, and they are usually short term.

The process of allostasis is of fundamental importance and that helps organisms to adjust or adapt actively to predictable or unpredictable events of life. Allostatic load refers to the total cost, the agency must pay allostasis restore stability. Allostatic overloadcan cause serious pathophysiology. There are two types of allostatic overload, suggested that the reaction of the supporters are in:

Type - I: this is when allostatic overload occurs due to increased demand for energy is outstripping supply and those who are in an emergency life history stage. If the noise is normal again declined allostatic load.

Type - II allostatic overload occur when demand for energy rises with social conflicts orany type of social impairment. In these cases, the normality of secretion of glucocorticoids and activities of other mediators such as allostasis, is restored CNS neurotransmitters, autonomic nervous system, inflammatory cytokines, growth. However, when chronically high levels of allostatic load then keep developing disease. It is something like this, when a dried single ever, be emphasized, despite that he did not help the body function resumed. This leads to the wearing ofBody of persons. Although human body is adaptable to wear but not allostatic overload for a very long period of time without danger.

Adaptogens that can help curb come allostatic load. Adaptogens are herbal or pharmaceutical substance, they are not toxic at regular doses and produce non-specific nature of immune response to stress. The restoration of normalcy in HPA-axis. Adaptogens new class of regulators of metabolic homeostasis and allostatic changes that weaken theHyperfunction system activity or increasing hypothyroidism systems.

Allostasis and Drug Addiction
Drug addiction or substance dependence is a chronic disease characterized by a compulsive tendency to take and try to administer drugs or substances to the level of coercion and wishes to allostatic overload expressed. Continued increase in admission raises overtaken the hedonic level and the individual with a negative emotional state when they nothem. Allostatic changes helps to identify the causes and effects of drug addiction in the neurobiological and neuro-adaptive systems. The reward system of the brain in drug addiction involves several important elements of the amygdale basal forebrain macrostructure. The change in stress and reward systems of the brain seems to stability in allostatic state in contradiction to keep homeostatic state, this shows the evolution of vulnerability andRecurrence of addiction. The state of allostatic longer abstinence is the most useful target for the treatment of drug addiction and behavioral disorders by pharmacological therapies. When dealing with recovery from addiction, it is important for the patient, will perform the functions of the brain, conscious and fully aware of how the component of allostasis refers to those addiction.



No comments:

Post a Comment